Dr.Daniel’s Glycypro for prostate enlargement and cancer.

Dr.Daniel’s Glycypro is a  well researched product containing highly medicinal herbal remedies for prostate problems such as seeds of pumpkin (Cucurbita pepo) and   liquorice (Glycyrrhiza glabra Linn)   extracted and formulated scientifically .

Prostate Prolems (enlargement and cancer). The prostate gland is a walnut-shaped gland that wraps around the urethra like a collar. It is part of a male reproductive system in man. One of its main functions  is to add fluid to sperm. Although the gland starts out small, it grows as  men age and this process is called benign prostatic hyperplasia (BPH). It is because during aging the male sex hormone testosterone get converted to a related compound, dihydrotestosterone which stimulates prostate cell proliferation. Eventually, an enlarged prostate can clamp down on the urethra, restricting the flow of urine from the bladder and semen. This leads to problems such as frequent urination, urine leakage,  urinary tract infections and pain at the time of ejaculation.

The symptoms of prostate problems are the following

  1. A frequent and urgent need to urinate. One may have to get up several times a night to go to the bathroom.
  2. Trouble starting a urine stream.
  3. A weak stream of urine or a small amount of urine passing every time.
  4. The feeling of unfinished urination.
  5. Leaking or dribbling urine.
  6. Small amounts of blood in your urine
  7. Problems with sexual function and performance, such as difficulty achieving erection or painful ejaculation

There are  only 2 drugs, finasteride (Proscar) and terazoin (Hytrin) to treat prostate enlargement in allopathic system of medicine.  Proscar is not effective for about 50% of men and also causes side effects like decreased libido, ejaculatory problems and loss of erection. Surgery is often resorted to reduce the size of prostate. But in folklore there are excellent medicines like pumpkin seeds. Dr James Duke, the well known American Ethnobotanist and Phytochemist, recommends liquorice and saw palmetto also for  treating this disorder (Green Pharmacy).

Cancer in Prostate gland is common in men after 60. Symptoms are similar to those of prostate enlargement. Prostate cancer is associated with urinary dysfunction as the prostate gland surrounds the prostatic urethra. Changes within the gland, therefore, directly affect urinary function. Because the vas deferens deposits seminal fluid into the prostatic urethra, and secretions from the prostate gland itself are included in semen content, prostate cancer may also cause problems with sexual function and performance, such as difficulty achieving erection or painful ejaculation. Advanced prostate cancer can spread to other parts of the body, possibly causing additional symptoms. The most common symptom is bone pain, often in the vertebrae (bones of the spine), pelvis, or ribs. Spread of cancer into other bones such as the femur is usually to the proximal part of the bone. Prostate cancer in the spine is  of low-risk and careful observation of the tumor over time is needed.  It  can also compress the spinal cord, causing leg weakness and urinary and fecal incontinence. The monitoring process may involve serial PSA, physical examination of the prostate, and/or repeated biopsies. The goal of surveillance is to avoid overtreatment and the sometimes serious, permanent side effects of treatment for a slow-growing or self-limited tumor that would never cause any problems for the person. For 50% to 75% of people with prostate cancer it will cause no harm before a person dies.

Aggressive prostate cancers are treated by surgery, radiation therapy and external beam radiation therapy, high-intensity focused ultrasound (HIFU), chemotherapy, oral chemotherapeutic drugs (Temozolomide/TMZ), cryosurgery or hormonal therapy.

The herbs used in Glycypro are the following
  1. Pumpkin seeds (Cucurbita pepo L.)

Pumpkins are pear shaped fruits obtained from a stout hispid annual wine, a native of America.  The flesh is pale and scentless; containing 4.5% carbohydrates and good amounts of vitamin C. The seeds are rich in fats (39%) and proteins (30%). The oil extracted from seeds is used for edible purposes and as a fuel. Pumpkins are also used in many squash preparations. Seeds are anthelmintic and used as a taenicide The seed oil contains  oleic, linoleic, and palmitic acids (44.11%, 34.77%, and 15.97% respectively) and found to be rich in tocopherols with a predominance of δ-tocopherol (42.27%). The sterol marker β-sisosterol accounted for 39.6% of total sterols contained in seed oil of this variety. Six phenolic acids (protocatechuic, caffeic, syringic, vanillic, p-coumaric and ferulic) were detected, the syringic acid being predominant (7.96 mg/100 g). It also contains cucurbitacins. In  addition,  pumpkin seeds are rich in zinc and amino acids like alanine glycine and glutamic acid.

Pumpkin seeds are the traditional treatment for BPH in Bulgaria, Turkey and Okraine. A handful of seeds per day throughout adulthood is recommended to keep prostate healthy. They are prescribed to treat ailments of the prostate gland. In particular, the seeds’ combination of high zinc content and diuretic effect makes it a good remedy for noncancerous prostate enlargement. And a Swedish clinical trial found that a substance called curbicin, obtained from pumpkin seeds and dwarf palms, noticeably improved the symptoms of enlarged prostate. Both zinc and cucurbitacins prevent transformation of testosterone to dihydrotestosterone . Amino acids such as alanine glycine and glutamic acid also are found useful in relieving BPH  symptoms.

Pumpkin seed oil is also reputed to be beneficial in ailments of the urinary system. A paper published in 1994 in the journal of Tongji Medical University describes the effectiveness of the seed oil in improving the function of the bladder and urethra. Pumpkin seeds have long been used to get rid of roundworms. The seeds are still a popular de-worming remedy, especially for children as they are nontoxic and safe. A Taiwanese study looking at purging the body of tapeworms (Taenia saginata) found a combination of pumpkin seeds and areca nuts to be safe and effective: the amino acid cucurbitine has known taeniacide (antitapeworm) properties.

Egyptian research published in 1995 found that pumpkin seed oil improved arthritic conditions, while a decoction of the seeds is used to remedy intestinal inflammation. Pumpkin flesh is high in fibre and acts as a gentle laxative. For external use, the flesh can be pulped and applied as a poultice to treat burns, while the oil is a soothing emollient.

The British Herbal Pharmacopoeia reported prostatic action (BHP, 1996) for pumpkin seeds. The Merck Index reports its therapeutic category as anthelmintic (Budavari, 1996). The constituents tocopherol and selenium may have a protective function towards the oxidative degradation of lipids, vitamins, hormones, and enzymes. Protein fractions of pumpkin seed are thought to function as trypsin inhibitors (Krishnamoorthi et al., 1990; Wichtl and Bisset, 1994). A recent review of studies on the therapeutic activity concluded that pumpkin seed inhibits 5α-reductase in vitro. In vivo, it has demonstrated anti-androgenic and anti-inflammatory activities (Bombardelli and Morazzoni, 1997).

In a multi centre controlled study involving more than two thousand subjects, a product containing pumpkin seeds was evaluated for the treatment of benign prostate hyperplasia (BPH). The results indicated that, not only were pumpkin seeds effective in reducing symptoms associated with BPH, especially in its early stages, but also no side effects were reported by the patients involved in the trial . In a Swedish study involving 53 patients, pumpkin seed reduced symptoms related to BPH, without any side effects. Other clinical trials also show that pumpkin seeds, along with other herbs, have a positive effect against mild to moderate BPH. A study in Egypt (Manal K Abdel-Rahman, 2006 )  conclude that pumpkin seed at 10% can inhibit citral-induced hyperplasia of the ventral prostate lobe as observed in reducing protein binding prostate levels, weight of ventral prostate lobe and improve histology of testis therefore may be beneficial in the management of benign prostatic hyperplasia.

Liquorice   (Glycyrrhiza glabra Linn.-  Fabaceae)

This glandular hairy herbaceous perennial, 1 m in height, bears pinnate leaves having 9-17 ovate leaflets, pale blue flowers in spikes and a 3-4 seeded red-brown glabrous pod. Liqorice, a native of southern Europe and western and central Asia, is cultivated on a mass scale in Spain, Turkey and U.S.S.R.

The roots contain saponin glycyrrhizin (2-9%) and a mixture of potassium and calcium salts of glycyrrhizinic acid as the major constituents. Also present are some other triterpenoid saponins such as glabranin A& B , glycyrrhetol, glabrolide and isoglabrolide; flavonoids such as licochalcone-A, glabridin, glucoliquiretin apioside, isoflavones like formononetin and glabrone, coumarins viz; herniarin, umbelliferone and sterols, onocerin,β-amyrin and stigmasterol

Liquorice prevents conversion of testosterone to dihydrotestosterone. Therefore it is used as a medicine in prostate enlargement. Products of liquorice are proved to be anticancer and cancer preventive. Isoliquiritigenin significantly inhibited the proliferation of prostate cancer cell lines. Licochalcone-A, glabridin, and licocoumarone have been tested using cancer cells growing in laboratory dishes, and preliminary studies indicate that these chemicals can stop the growth of or even kill prostate cancer, breast cancer and leukemia cells.  The best known herbal products for prostate cancer treatment such as PC-HOPE and PC-CARE contains liquorice..  The crude drug exhibits demulcent, expectorant, antimicrobial, antihepatotoxic and anti-inflammatory properties due to glycyrrhizin. It is also useful in treating peptic ulcer. Oral doses of liquorice is used for gastric, duodenal and oesophageal ulceration or inflammation, heartburn  and  mouth ulcers. It prevents infections of urinary tract and  used in Chinese medicine as an emmenagogue. Glycyrrhizin extract is used for chronic hepatitis. Glycyrrhetinic acid exhibits a specific antitumour activity and is a  cytostatic. It also induces phenotypic reversion i.e. the cancer cells get converted back more like normal cells

The main benefits of Glycypro are summarized below
  1. Heals prostate enlargement and prostate cancer.
  2. Enlarges ureter and prevents  uncontrolled urine leakage
  3. Prevents frequent urination.
  4. Regular use prevents prostate enlargement and prostate cancer.