Dr. Daniel’s Terogena.
Terogena is a formulation, developed by the well-known phytochemist, Prof. M. Daniel and his teamin Dr. Daniel’s Laboratories after extensive research, of well-known scientifically proved plants in the most effective combination. Along with the proven antidiabetic plants, other medicinal plants which are rich in antioxidants and protect the heart, liver and kidney as well as increasing stamina are added in this combination. The plants used in Terogena, their active principles and their clinically proven activities are summarized below.
- Amala (Emblica officinalis Gaertn) fruit is a rich source of gallic acid and gallotannins like emblicanin which is vitamin C like in action. The extract of this fruit, which is very rich in antioxidants, is found to reduce serum glucose levels, prevents cancer and is hypolipidaemic, antiaging, hepatoprotective and cardioprotective (Sukhdev, 2006)
- Gudmaar (Gymnema sylvestre R.Br.) is the well-known ‘Madhunaashi’ containing triterpenoid glycosides such as gymnemic acids, gymnemosides and gymnema saponins. The leaf extracts are found to reduce blood glucose, and corrects abnormal lipid levels (cholesterol, triglycerides etc) caused by diabetes. This plant is sold in markets of USA, Japan and Germany as a health food. This plant prevents tooth decay and obesity.
- Sariva (Hemidesmus indicus R.Br.) This is one of the rasayana drugs used to revitalise human body. The roots contain coumarino-lignoids such as hemidesminine. Sariva possesses great antioxidant activities and is a blood thinner. It has proven anti-inflammatory as well as hepatoprotective activities (Prabhakaran and Co-workers, 2000).
- Arjuna ( Terminalia arjuna W.& A. ). Arjuna bark contains a number of triterpenoids such as arjunic acid and arjunolic acid. This drug takes care of all the problems of lipid profile caused by diabetes and keeps the heart healthy. It is also anticancer and antioxidant in nature.
- Vijaysar (Pterocarpus marsupium Roxb.). This plant is rich in flavonoidal glycosides marsupin and pterosupin and kinotannin. The drug is found to reduce blood glucose levels, hypolipidaemic and reduces blood pressure (Sharma, 1986).
- Galo ( Tinospora cordifolia Miers) This is the famous ‘Amruta’, which is a well known Rasayana drug. It contains diterpenoids like columbin and chasmanthin as also an ecdysteroid. Galo exhibits hypoglycemic (reducing blood and urine sugar), antioxidant, immunomodulatory, antiarthritic and anticancer properties (Prince and Co-workers, 2001).
- Jamun beej (Syzygium cuminii L.). The seeds yield phenolics like guaiacol, veratrol and gallic acid. They are antidiabetic in nature increasing insulin levels in blood serum and reducing fasting glucose levels (Grover and co-workers, 2002). The drug is found to increase muscle and liver glycogen content also. Seeds are found to reduce serum cholesterol and LDL and raised HDL (Sharma and co-workers, 2003)
This formulation of plants (Terogena) was subjected to a critical study in Botany Department of the Maharaja Sayajirao University of Baroda, Vadodara by Prof. Daniel and his team (Remya, 2009) for: 1). Its efficacy in reducing blood and urine sugar in diabetic rats, 2).Hypoglycemic activity (to check the lowering of blood glucose in normal rats), 3). effect of the extracts on enzymatic (SOD, CAT, and GPX) and non-enzymatic antioxidants, 4).Effect of the extracts on lipid peroxidation (TBARS, GSH, vitamin C and vitamin E), 5) Effect of the extracts on carbohydrate metabolizing enzymes (hexokinase, glucose-6-phosphatase and fructose-1, 6-bisphosphatase), 6).Effect to retrieve the renal toxicity caused due to diabetes (urea, uric acid, creatinine and blood urea nitrogen – BUN) and 7). Antihyperlipidaemic effect (cholesterol, free fatty acids, triglycerides, phospholipids, LDL, VLDL and HDL).
Terogena caused up to 65.2% reduction in the blood glucose level. It also improved the body weight by 30.1%.The levels of TBARS were decreased in plasma, liver, kidney, and in brain. The level of GSH and vitamin C was increased in plasma, liver, kidney and in brain. There was a decrease in the plasma vitamin E while its level was increased in liver, kidney and brain. Terogena also caused increased activities of SOD, CAT and GPX. The formulation reduced levels of urea, uric acid and creatinine in plasma.
Due to the administration of Terogena, the activities of glucose-6-phosphatase and fructose-1,6-bisphosphatase were reduced but the activity of hexokinase increased. Lipid levels such as cholesterol, triglycerides, free fatty acids, phospholipids, LDL and VLDL were decreased while increased level of HDL was observed. When given to normal rats this formulation did not reduce sugar level indicating that it is a safe drug. All these results are published in the book “Studies on some Indian antidiabetic plants” written by Prof. Daniel in 2012.
In conclusion, it is experimentally proved that Terogena reverses the changes of diabetic complications thereby acting as a potent antidiabetic, antioxidant and antilipidaemic herbal formulation. It also reverses the changes of carbohydrate metabolizing enzymes by increasing the activity of hexokinase which can decrease the level of blood glucose. Terogena possesses hypolipidaemic effect and increased haemoglobin content. The formulation also protects the body from oxidative stress by increasing the antioxidants. Apart from that, it also protected the diabetic induced renal damage by decreasing the level of urea, uric acid and creatinine in the blood. The formulation shows better effect than the standard drug glibenclamide.